Field cancerization treatment using topical photodynamic therapy: A comparison between two aminolevulinate derivatives
Ramos de Oliveira, Elisangela Inada, Natalia M. Blanco, Kate Cristina Bagnato, Vanderlei S. Salvio, Ana Gabriela
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DOI/PMID/Link: 10.1016/j.pdpdt.2019.101603
Abstract
The objective of this study was to evaluate and compare the clinical response to PDT (Photodynamic Therapy) in field cancerization using two aminolevulinate derivatives. Forty patients with multiple actinic keratosis (AK) on forearms and hands scattered received two sessions of ALA and MAL-PDT at 630 nm (36 J/cm2). The AK clearance rate was 72 % for both drugs with a significant decrease in AK observed clinically (p < 00,001). Clinical improvement in field cancerization using two aminolevulinate derivatives in PDT is proven with no significant difference in the efficacy of drugs.
| Year Published | 2020 |
|---|---|
| Country | Brazil |
| Rank | Positive |
| Journal | Photodiagnosis and Photodynamic Therapy |
| Primary Topic | Skin |
| Secondary Topic | Cosmetic Skin Conditions |
| Tertiary Topic | Actinic Keratosis |
| Model | Human |
| Wavelength (nm) | |
| Complement/Comparison | Aminolevulinic Acid |